Mental illness, notably depression, is gradually garnering the necessary attention it deserves. Treatment options are now accessible, but a notable challenge has arisen: the identification of treatment-resistant depression.
Treatment-resistant depression (TRD) poses a significant challenge to mental health, increasing the likelihood of both morbidity and mortality. Addressing this condition requires a comprehensive and nuanced approach to improve outcomes and enhance overall well-being.
In light of challenges such as TRD or ineffective treatments, researchers are exploring alternative avenues. This is where psychedelics like DMT come into consideration.
Key Takeaways:
- DMT is a hallucinogenic substance that shows a positive impact on treating depression.
- Most studies suggest that DMT has a neuroplastic ability, which can support positive changes to alleviate depression.
- DMT is potent, so taking small amounts is best for beginners.
What is DMT?
DMT (N, N-dimethyltryptamine) comes with multiple monikers.
- Fantasia
- Dimitri
- Spiritual molecule
- Businessman’s special
- 45-minute psychosis
- Businessman’s trip
This substance falls under the category of psychedelics. It shares similar effects with magic mushrooms and LSD. Despite sharing the hallucinogenic effects, DMT also stands out on its benefits and how it actually affects the human body.
Effects of DMT
Before we dive into how DMT affects the human brain to potentially assist with mental health conditions, let’s first explore its effects.
- Elevated perceptions of perception, such as considering colours to be far more intense than they actually are, sounds to be sharper, touch to be more sensitive, etc.
- Perception of sounds, smells, or sensations that are not genuine
- Mixed sensory experiences, or synesthesias, include delusions of hearing colours, seeing sounds, etc.
- Cognitive alterations include delusions that one is not who they are or has changed into an inanimate object.
- A shift in how time seems to pass, such as the perception that time flows much more slowly than it actually is.
- Strong illusions that embody ideas devoid of empirical validation
How is DMT Helping Depression Treatment
Studies or Proof
| STUDIES | RESULTS |
| Phase I/IIa study conducted by Dr David Erritzoe and associates. Dr. Erritzoe is a Clinical Psychiatrist at Imperial College London and the study’s Chief Investigator. | Two weeks after taking SPL026 (intravenous DMT) with supportive therapy, there was a statistically significant and clinically meaningful decrease in depressed symptoms when compared to placebo. There was no discernible difference in the antidepressant effect between an intravenous DMT dosing regimen of one and two. |
| January 2021, Centre for Psychedelic Research at the Imperial College London | Depression that is resistant to treatment may be helped by DMT. It seems to boost brain “plasticity,” which facilitates a quicker pace of change. |
| Yale study, Nature Journal Neuropsychopharmacology | With the higher dose, patients’ depression scores dropped by 4.5 points. |
How DMT Works When Treating Depression
Selective SSRIs and MAOIs lend a helping hand to neurotransmitter levels in the brain. However, they miss the source of depression.
To enhance well-being, SSRIs and MAOIs prevent neurotransmitter reuptake. They alter the quantity of neurotransmitters that regulate emotions of well-being.
According to the studies above, DMT supports neuroplasticity. It encourages the expansion of neurons and stronger synaptic connections. It changes brain chemistry in a way that facilitates sustained depression alleviation. Alternatively, DMT encourages heightened emotions of joy and well-being, which is not experienced through traditional medications.
DMT Products Available for Treating Depression Symptoms
Vaping is the most popular way to use DMT products. When using a portable device called a vape, you inhale vapour rather than smoke. Because vapour is less damaging to the lungs than smoke, you can take DMT without risking lung damage.
Dream Machine – Vape Cartridge
Every inhale of this vape juice is like a dream, true to the moniker Dream Machine. You get to investigate union with the universal source code, hyperdimensional spaces, and sentient entities.
Discover this breathtaking, all-consuming phenomenon that becomes apparent to those brave enough to look.
Amount: 1 gram
Integral Alchemist – Acacia – DMT Vape Cart
Integral Alchemist cape carts are the most convenient way to share DMT with others. You can use them while traveling and avoid fumbling with complicated equipment or lighters. Strong enough for breakthroughs with ease (up to 15 per cart).
Amount: 1 mL
Also available in Integral Alchemist – Mimosa
Lucid Supply Co. – 5-MeO DMT Vape Cart
5-MeO-DMT is closely related to N, N-DMT. Since 5-MeO-DMT is only present in the secretions of certain frog species (the Colorado River Toad and the Sonoran Desert Toad), it is commonly referred to as “Toad Venom” or “The Toad.”
5-MeO-DMT provides a sensation that lasts for 15 to 20 minutes. During that time, you might not even realize time is passing.
Amount: 125mg/0.5mL 5-MeO-DMT
Also available in Lucid Supply Co. – N, N- DMT Vaporizer – 300mg/0.5mL Cartridge
Lucid Supply Co. – Pure 5-MeO DMT Crystal (Freebase)
Freebase DMT is the pure alkaloidal form of N, N-Dimethyltryptamine. It refers to extracts with DMT as their principal, though not exclusive, active ingredient in freebase form. This is the type of DMT that is most frequently administered by inspiration—that is, by heating it until it vaporizes.
It appears as a transparent, white crystalline product in its pure form with a consistent structure.
Amount: 500mg
Also available in Lucid Supply Co. – Pure N, N-DMT Crystal (freebase) – 500mg
Osmosis – Ethereal Essence 4-ACO-DMT Tincture
The purpose of these (4AcO-DMT) drops is to assist people who are pursuing empowerment and self-improvement. Using Ethereal Essence may have the unintended consequence of causing one to transcend ego-dominating forms of living.
How to Use DMT Safely
You can take some sensible precautions to make sure you’re safe and healthy when using this potent psychedelic.
- Dosage is one important consideration; it is best to start with a low dose because DMT can be very strong, even at low concentrations.
- It’s also a good idea to have a sitter or trustworthy friend with you while you do DMT. If the consequences become too much for you to handle, this individual can help maintain your emotional stability, help keep you safe physically, and keep you grounded.
- The ideal setting for using DMT would be your home or the place of a reliable buddy. Make sure there are no distractions or possible causes of stress in the area and that it is cozy.
- It would be ideal if you become knowledgeable about the possible interactions or contraindications. You can use this information to decide when and how to use the substance.
Conclusion
The potential benefits of DMT for treating depression make it a fantastic substitute therapy. Some users assert they are experiencing the benefits despite the need for additional proof to support its potential benefits. Investigating DMT can be beneficial, but novices should exercise caution. It’s always possible to start slowly and assess how the dosage affects your health.
Frequently Asked Questions
What is the onset and duration of DMT?
Injected or inhaled DMT takes effect quickly. The effects may take effect in a matter of minutes.
The following factors affect how intense and long a DMT trip is:
- The amount you utilize
- Way you employ it
- Whether you’ve consumed food or used other medications
The effects of injected, snorted, or breathed DMT often last between 15 to 60 minutes. When using DMT in a brew, the effects usually take longer to manifest.
How long does DMT stay in the body?
DMT doesn’t stay for very long. It is broken down by a number of organs, including the liver, into smaller parts that the kidneys and urine can then eliminate.
DMT remains in the body for about an hour. Levels peak at 10 to 15 minutes, and thereafter, they significantly decline. DMT is completely undetectable in the system after 60 minutes.
How does it feel coming down after a DMT trip?
DMT has very few comedown effects compared to other hallucinogens. Most people begin to come down after 10 to 15 minutes. DMT blood concentrations decrease to the point where brain chemistry starts to normalize again.
People frequently mention feeling confused at this point. Some report feeling a little uneasy or having trouble falling asleep in the days after the trip. Still, long-term consequences seem to be minimal overall.
Where can I buy DMT?
Purchasing DMT items from a reliable online dispensary is the safest and most practical option. Numerous advantages provided by online sellers ensure both the product’s cost and quality.
- They source their products from local brands with authorization and experience.
- They offer multiple options like tinctures, vape carts, or crystals.
- The price range is lower than buying from a physical store or dealer.
- There are multiple ways to reduce prices, like 20% off for first-time buyers.
- They can ship anywhere in Canada (make sure to check the shipping policy first).
What does a DMT “breakthrough” experience entail?
The term “breakthrough” DMT experience refers to a particularly potent and profound experience that some users describe having while taking high quantities.
- Complete detachment from reality
- Intense visual and auditory hallucinations
- A sense of transcending or ego death
- A sensation of entering a different dimension or realm
This experience can be both pleasant and challenging, depending on the person’s views and experiences. It appears as a deeply spiritual or mystical event.
