The US Secret Service is investigating to know how cocaine found its way to the White House.
The discovery was made in the West Wing, which contains the Oval Office and other working areas for presidential aides and staff.
The suspected cocaine powder was found in an area that is accessible to tour groups by the Secret Service during a routine inspection.
The discovery led to a brief evacuation and closure at the House House at about 20:45 local time (00:45 GMT) on Sunday.
Joe Biden and his family were away at Camp David in Maryland when the cocaine was found.
Authorities said that controlled substance was found in a storage facility routinely used by White House staff and guests to store mobile phones.
The Secret Service said it will examine its cameras and entrance logs to know who had accessed the area where it was found.
The West Wing, where the cocaine was found is a large, multi-level part of the White House that contains the offices of the president of the United States, including the Oval Office and the Situation Room.
It also has offices of the vice president, the White House chief of staff, the press secretary, and hundreds of other staff who have access.